Senior Scientist, Immuno-Oncology Job


Merck & Co., Inc. Kenilworth, N.J., U.S.A. known as Merck in the United States and Canada, is a global health care leader with a diversified portfolio of prescription medicines, vaccines and animal health products. Today, we are building a new kind of healthcare company – one that is ready to help create a healthier future for all of us.

Our ability to excel depends on the integrity, knowledge, imagination, skill, diversity and teamwork of an individual like you. To this end, we strive to create an environment of mutual respect, encouragement and teamwork. As part of our global team, you’ll have the opportunity to collaborate with talented and dedicated colleagues while developing and expanding your career.

We are seeking a highly motivated and skilled research scientist to join the Immuno-oncology Discovery team at Merck in Boston. You will be responsible for designing, executing and reporting the results of experiments to support projects from target identification and validation through to clinical candidate selection, as well as supporting the development and clinical pipelines with basic biology and pharmacology studies. You will use a wide range of advanced methodologies to probe mechanisms and test drugs, primarily through in vitro and ex vivo cell-based immunological assays. The successful candidate will have excellent oral and written communication skills, work well independently and as part of a team, and be able to execute on multiple projects simultaneously. With limited supervision, the role includes developing and optimizing methodologies and assays and making decisions using good scientific judgment. The position is a hands-on, laboratory based role with no direct reports.



- Bachelor’s degree in immunology, cell biology, pharmacology, or related field with a minimum of 3 years' experience (Doctoral) OR a minimum of 4 years’ experience (Masters) OR a minimum of 7 years’ experience (Bachelors) in the pharmaceutical/biotech industry or in an academic setting.


- Cell line and primary immune cell tissue culture skills.

- Ability to independently design, perform and interpret data derived from cellular immune function assays (e.g. differentiation, proliferation, cytotoxicity, cytokine production).

- Broad expertise and familiarity with assays and technologies commonly used to assess immune endpoints (e.g., MLR, antigen-specific T/APC cultures, ELISA, Mesoscale).

- Experience with cell separation technologies (e.g., Miltenyi, AutoMACS) and FACS sorting.

- Experience in multi-parameter flow cytometry and proficiency in downstream FACS data analysis programs such as FlowJo, FACSDiva, etc.

- Ability to organize and communicate complex data sets in a clear and concise manner to key stakeholders from diverse backgrounds.

- Basic understanding of statistics, data analysis, and assessment of reproducibility and reliability of experimental data.


- Cell line engineering for assay development, molecular biology, PCR technologies, genetic manipulation.

- Directing and coordinating work with external academic or industry partners, or with contract research organizations.

- Mentoring and training junior scientists.

- Experience with humanized mouse models applied to tumor immunology

- Proven experience with biologics drug discovery and demonstrable knowledge of multiple large molecule formats and associated technologies

- Demonstrable experience with handling and in vitro pharmacological characterization of small molecule drugs, e.g. potency titration, experimental design and replication.

- Experience authoring peer-reviewed scientific publications and / or presenting at scientific conferences, particularly in the field of immuno-oncology.

- Isolation, characterization and functional testing of primary human immune cells from healthy donors or patient-derived materials.

Our employees are the key to our company’s success. We demonstrate our commitment to our employees by offering a competitive and valuable rewards program. Our Company’s benefits are designed to support the wide range of goals, needs and lifestyles of our employees, and many of the people that matter the most in their lives. If you need an accommodation for the application process please email us at

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Visa sponsorship is not available for this position.

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Job: Biology-Discovery

Job Title:Sr. Scientist, Biology-Discovery

Primary Location: NA-US-MA-Boston

Employee Status: Regular

Travel: Yes, 5 % of the Time

Number of Openings: 2

Shift (if applicable): 1st

Hazardous Materials: Chemicals, biologicals

Company Trade Name:Merck

Nearest Major Market: Boston
Job Segment: Chemistry, Oncology, Genetics, Scientific, Biotech, Science, Healthcare, Engineering

Open Date: February 16, 2016
Close Date:
Location: Boston, MA, US
Contact: To Apply click HERE
Attachment: N/A