Merck - Senior Scientist, Immunology Job


Merck & Co., Inc. Kenilworth, N.J., U.S.A. known as Merck in the United States and Canada, is a global health care leader with a diversified portfolio of prescription medicines, vaccines and animal health products. Today, we are building a new kind of healthcare company – one that is ready to help create a healthier future for all of us.

Our ability to excel depends on the integrity, knowledge, imagination, skill, diversity and teamwork of an individual like you. To this end, we strive to create an environment of mutual respect, encouragement and teamwork. As part of our global team, you’ll have the opportunity to collaborate with talented and dedicated colleagues while developing and expanding your career.

We are seeking a highly motivated, independent, and skilled research scientist to join the Immunology Discovery team at Merck in Boston. With limited supervision, s/he will be responsible for designing, executing, and reporting the results of experiments to support and advance projects from target identification and validation through to clinical candidate selection, as well as supporting the development and clinical pipelines with basic biology and pharmacology studies. S/he will use a wide range of advanced methodologies to define drug potency and mechanism(s)-of-action, primarily through in vitro and ex vivo cell-based immunological assays in both mouse and human systems.

Broad expertise in immunobiology is required for this role, with preference given to candidates with demonstrated experience in drug discovery and development. S/he will have excellent oral and written communication skills, work well independently and as part of a team, and be able to contribute to multiple projects simultaneously. This position is a hands-on, laboratory based role with no direct reports.



- Ph.D. in immunology, cell biology, pharmacology, or related field with 3+ years' experience in the pharmaceutical/biotech industry or in an academic setting.
- Outstanding candidates with a Master’s degree with 5+ years’ industry experience will also be considered.


- Solid training and background in cellular immunology, preferably with area expertise in one or more of the following: autoimmunity & inflammation, immuno-oncology, infectious disease (including familiarity with associated rodent pre-clinical models).
- Ability to independently design, perform and interpret data derived from cellular immune function assays (e.g., differentiation, proliferation, cytotoxicity, cytokine production).
- Broad expertise and familiarity with assays and technologies commonly used to assess immune endpoints (e.g., MLR, antigen-specific T/APC cultures; ELISA/ELISPOT, Mesoscale, Luminex; qPCR, NanoString); solid cell line and primary immune cell tissue culture skills.
- Experience in multi-parameter FACS analysis (e.g., BD LSR/Canto, MACSQuant) and proficiency in downstream FACS data analysis programs such as FlowJo, FACSDiva, or FCS Express; experience with cell separation technologies (e.g., magnetic bead-based isolation or FACS-based sorting).
- Ability to organize and communicate complex data sets in a clear and concise manner to key stakeholders from diverse backgrounds.
- Ability to contribute at a scientific and strategic level to drug discovery research programs in immunology, including proposal and identification/validation of novel targets.
- S/he should be a strong team player with excellent oral and written communication skills and a demonstrated ability to work independently to design experiments, generate and interpret data, troubleshoot, and suggest next steps.


- Experience directing and coordinating work with external academic or industry partners, or with contract research organizations.
- Demonstrated project lead experience in an academic or industrial research setting.
- Demonstrated experience mentoring and training junior scientists.
- Proven experience with biologics drug discovery and demonstrable knowledge of multiple large molecule formats and associated technologies.
- Experience with in vivo immune-mechanistic or autoimmune/cancer disease models in the mouse system and their application towards pharmacological assessment of drug efficacy and mode-of-action.
- Demonstrable experience with in vitro pharmacology assays involving large or small molecule drugs, e.g., experimental design and replication, titration and potency value determination, etc.
- Experience with isolation, characterization, and functional testing of primary human immune cells from healthy donors or disease patient-derived materials.
- Genetic engineering of reporter cell lines and/or primary cells: molecular biology skills (e.g., plasmid manipulation and transfection, clonal selection) and experience with gene editing technologies (e.g., si/shRNA and CRISPR/Cas9 via transfection or retroviral delivery).

Our employees are the key to our company’s success. We demonstrate our commitment to our employees by offering a competitive and valuable rewards program. Our Company’s benefits are designed to support the wide range of goals, needs and lifestyles of our employees, and many of the people that matter the most in their lives. If you need an accommodation for the application process please email us at

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Merck & Co., Inc. is not accepting unsolicited assistance from search firms for this employment opportunity. Please, no phone calls or emails. All resumes submitted by search firms to any employee at Merck via email, the Internet or in any form and/or method without a valid written search agreement in place for this position will be deemed the sole property of Merck. No fee will be paid in the event the candidate is hired by Merck as a result of the referral or through other means.

Visa sponsorship is not available for this position.

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Merck is an equal opportunity employer, Minority/Female/Disability/Veteran – proudly embracing diversity in all of its manifestations.

Job: Biology-Discovery

Job Title:Sr. Scientist, Biology-Discovery

Primary Location: NA-US-MA-Boston

Employee Status: Regular

Travel: No

Number of Openings: 1

Shift (if applicable): 1st

Hazardous Materials: Healthy donor human blood work; limited chemical use, such as formaldehyde solutions for cell fixation

Company Trade Name:Merck

Nearest Major Market: Boston
Job Segment: Chemistry, Genetics, Biotech, Scientist, Oncology, Science, Healthcare

Open Date: May 2, 2016
Close Date:

Boston, MA

For more info and to apply, click HERE.
Attachment: N/A